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roxS [2020-09-09 16:25:54]
small RNA, controls expression of [gene|B729EFC0BF0D75765C2D2B0B4F397E0AEE11F1E7|ytdI], [gene|D72175937B3956C2BC500FC00CEC8EC57A0A76A8|sucC]-[gene|5900CAC1CE367F33B267673A7FC210A3A269B30E|sucD], and [gene|search|yflS ]
function
control of [gene|B729EFC0BF0D75765C2D2B0B4F397E0AEE11F1E7|ytdI], [gene|D72175937B3956C2BC500FC00CEC8EC57A0A76A8|sucC]-[gene|5900CAC1CE367F33B267673A7FC210A3A269B30E|sucD], and [gene|search|yflS ]expression
product
trans-acting regulatory RNA
Genomic Context
categories
[category|SW 6|Groups of genes] → [category|SW 6.9|NcRNA] → [category|SW 6.9.5|Regulatory RNAs]RNA
Catalyzed reaction/ biological activity
hybridizes to [gene|B729EFC0BF0D75765C2D2B0B4F397E0AEE11F1E7|ytdI] and [gene|5900CAC1CE367F33B267673A7FC210A3A269B30E|sucD] mRNAs to inhibit their translation and to destabilize them [pubmed|25643072]binds the 5' end of the [gene|73356B73D6C89D6569CECCC7295AF85CC7A1E6E3|yflS] mRNA to prevent its degradation by [SW|rnjA|RNase J1] [pubmed|28436820]Expression and Regulation
Operons
genes
[gene|6AC80B5916EEA851E9A7AF586341C58B7E69D8E7|roxS]
description
[pubmed|22383849]regulatory mechanism
[protein|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|ResD]: transcriptional activation, [pubmed|22383849], in [regulon|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|ResD regulon][protein|B5EF521437323EF43F08E5EFDB5C798616CA499A|Rex]: repression, [pubmed|28436820], in [regulon|B5EF521437323EF43F08E5EFDB5C798616CA499A|Rex regulon]regulation
induced by nitric oxide (NO) ([protein|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|ResD]) [pubmed|22383849][protein|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|ResD]: transcriptional activation [pubmed|22383849][protein|B5EF521437323EF43F08E5EFDB5C798616CA499A|Rex]: transcriptional repression [pubmed|28436820]additional information
the [gene|search|roxS ]RNA is degraded by the joined activities of RNase Y (initial endonucleolytic cleavage) and RNase J1 (processive degradation) [pubmed|22383849]the [gene|6AC80B5916EEA851E9A7AF586341C58B7E69D8E7|roxS]-[gene|search|ppnKB ]and [gene|6AC80B5916EEA851E9A7AF586341C58B7E69D8E7|roxS]-[gene|search|sucC ]RNA duplexes form a cleavage site for RNase III [pubmed|22383849]view in new tabBiological materials
mutant
available in [SW|Ciaran Condon]'s lab [pubmed|25643072]References
